Asymmetric indium-mediated synthesis of homopropargylic alcohols |
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Authors: | Lacie C Hirayama |
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Institution: | Department of Chemistry and Biochemistry, University of California at Santa Cruz, 1156 High St, Santa Cruz, CA 95064, United States |
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Abstract: | A method for the enantioselective synthesis of homopropargylic alcohols using indium under Barbier-like conditions is reported herein. Both aromatic and aliphatic aldehydes were successfully converted to the corresponding homopropargylic alcohols in good yield and high enantiomeric excesses using propargyl bromide, indium, and (1S,2R)-(+)-2-amino-1,2-diphenylethanol as a chiral auxiliary. |
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