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Tandem enlargement of the tetrahydropyridine ring in 1-aryl-tetrahydroisoquinolines using activated alkynes—a new and effective synthesis of benzoazocines |
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| Authors: | Leonid G. Voskressensky Tatiana N. Borisova Anna V. Listratova Larisa N. Kulikova Alexander A. Titov Alexey V. Varlamov |
| Affiliation: | Organic Chemistry Department of the Russian People Friendship University, 6, Miklukho-Maklaia St., Moscow 117198, Russia |
| Abstract: | Tetrahydroisoquinolines 3a-e underwent piperidine ring enlargement under the action of activated alkynes, giving benzoazocines 4, 5 and 7-11 in high yields. |
| Keywords: | Tetrahydroisoquinoline Azocines Glaucine Alkyne Tandem reactions |
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