A concise synthesis of 7-chloro-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carbonitrile, a versatile intermediate for substituted 6-cyanothiazolopyridines |
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| Authors: | Sigmond G. Johnson Peter J. Connolly William V. Murray |
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| Affiliation: | Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA |
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| Abstract: | We describe the development of a simple route for the preparation of the novel title intermediate thiazolo[4,5-b]pyridine. This intermediate was particularly well suited for derivatization at the C-2 and C-7 positions of the bicyclic ring system. |
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