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A convenient method for N-1 arylation of uracil derivatives |
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| Authors: | Andrzej Gondela |
| Institution: | Department of Organic Chemistry, Biochemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland |
| Abstract: | 1-(4-Nitrophenyl)- and 1-(2,4-dinitrophenyl)uracil derivatives have been obtained by direct arylation of uracil and its 5-substituted derivatives using 1-fluoro-4-nitrobenzene or 1-fluoro-2,4-dinitrobenzene in the presence of a base. The application of the newly obtained uracil derivatives in further synthesis is also presented. |
| Keywords: | 5-Substituted uracil derivatives 5-Nitro-1-(4-nitrophenyl)uracil 1-(2 4-Dinitrophenyl)-5-nitrouracil Nucleophilic aromatic substitution ANRORC type reaction |
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