Deprotection of heteroaromatic carbamates via a base-catalyzed methanolysis |
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| Authors: | Wen-Chung Shieh Song Xue Joe McKenna Kapa Prasad Oljan Repi? Thomas Blacklock |
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| Affiliation: | Process R&D, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA |
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| Abstract: | A simple and mild method for the deprotection of heteroaromatic carbamates via methanolysis using a catalytic amount of base such as sodium methoxide, DBU, or Verkade’s base (proazaphosphatranes) is presented. Carbamate protecting group of an aliphatic amine is not affected under these conditions. |
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