Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines |
| |
| Authors: | Christian AGN Montalbetti Thomas S Coulter Serge G Reignier Charlotta Grånäs Jakob Felding |
| |
| Institution: | a Evotec, 111 Milton Park, Abingdon, Oxon OX14 4RX, United Kingdom
b BioImage A/S Mørkhøj Bygade 28, DK-2860 Søborg, Denmark |
| |
| Abstract: | We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound. |
| |
| Keywords: | Triazine Sonogashira Suzuki Nucleophilic substitution PI3 Kinase pathway inhibitors FOXO1 Translocation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
