Preparation and synthetic application of methyl β,β-difluoro-α-trimethylsilyloxyacrylate: a fluoride ion-promoted desilylative-defluorination route |
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| Authors: | Go Takikawa |
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| Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Okayama University, Okayama 700-8630, Japan |
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| Abstract: | Catalytic amount of TBAT (0.2 mol %) promoted desilylation and subsequent defluorination of ketene silyl acetal of methyl O-trimethylsilyltrifluorolactate, affording methyl β,β-difluoro-α-trimethylsilyloxyacrylate in 95% yield of which reaction with electrophiles provided methyl β-substituted-β,β-difluoropyruvate in good yields. |
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