7-Substituted prostaglandin analogues. A new synthetic approach |
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| Authors: | Witold Danikiewicz Tadeusz Jaworski Stefan Kwiatkowski |
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| Institution: | (1) Faculty of Chemistry, Technical University (Politechnika), PL-00-664 Warsaw, Poland;(2) Present address: Institute of Organic Chemistry, Polish Academy of Sciences, PL-00-224 Warsaw, Poland |
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| Abstract: | Starting from methyl 7-oxo-7-(1-cyclopentene)-heptanoate, a simple synthesis of the methyl esters of 7-oxo- and 7-hydroxy-9,11-dideoxy-PGF
1 as a model for 7-substituted prostaglandin analogues is described.
7-Substituierte Prostaglandin-Analoge — ein neuer Syntheseweg Zusammenfassung Ausgehend von Methyl-7-oxo-7-(1-cyclopenten)-heptanoat wird eine einfache Synthese der Methylester von 7-Oxo- und 7-Hydroxy-9,11-dideoxy-PGF
1 als Modellverbindungen für 7-substituierte Prostaglandinanaloge beschrieben. |
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| Keywords: | 7-Oxo-prostaglandins 7-Hydroxy-prostaglandins Nucleophilic 1 4-addition Nef reaction Wittig-Horner reaction |
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