Etude en Résonance Magnétique Nucléaire et Stéréochimie d'un Composé Cyclopropanique d'Intérět Thérapeutique. Résonance du Proton à 250 MHz avec Triple Irradiation |
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Authors: | C Gey R Perraud J L Pierre H Cousse L Dussourd D'Hinterland G Mouzin |
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Abstract: | 1-Pivaloyl-2-hydroxymethylcyclopropane is studied with nuclear magnetic resonance. The C-1? C-2 configuration is determined from the 250 MHz n.m.r. spectrum (triple irradiation experiments have been performed for this purpose). Rotational isomerism around the ring-carbonyl bond is studied from the ASIS effect. Rotational isomerism around the ring-hydroxymethyl bond is studied from vicinal coupling constants over a temperature range of ?20 to +125°C. From the J(HOCH) coupling constant (in CCl4) rotamer populations of the hydroxyl group are examined and the overall conformational distribution can be established. |
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