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Iodine-mediated direct synthesis of multifunctional 2-aminobenzimidazoles from N-substituted o-diaminoarenes and isothiocyanates |
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| Authors: | Zhen Wang Qiongli Zhao Jiao Hou Wenquan Yu Junbiao Chang |
| Affiliation: | 1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan Province, 450001, China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou University, Zhengzhou, Henan Province, 450001, China;3. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan Province, 450001, China |
| Abstract: | Multifunctional 2-aminobenzimidazoles were directly synthesized through sequential addition of N-substituted o-diaminoarenes to isothiocyanates, formation of carbodiimides via I2-mediated oxidative desulfurization, and intramolecular cycloaddition. This efficient and eco-friendly synthetic process provides a facile access to diverse 2-aminobenzimidazole derivatives from readily accessible substrates under mild reaction conditions in a scalable fashion. |
| Keywords: | Iodine 2-Aminobenzimidazole Isothiocyanate Desulfurization |
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