Transition-metal-free,atom-economical cascade synthesis of novel 2-sulfonated-benzo[f][1,7]naphthyridines and their cytotoxic activities |
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| Authors: | Sateesh Kumar Arepalli Yunseon Choi Kiho Lee Jong-Soon Kang Jae-Kyung Jung Heesoon Lee |
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| Institution: | 1. College of Pharmacy, Chungbuk National University, Chungbuk 28160, Republic of Korea;2. College of Pharmacy, Korea University, Sejong 30019, Republic of Korea;3. Korea Research Institute of Bioscience and Biotechnology, Chungbuk 28116, Republic of Korea |
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| Abstract: | An efficient, transition-metal-free cascade synthetic method has been developed for new 2-aryl/heteroaryl sulfonated benzof]1,7]naphthyridines. It is tert-butyl hydroperoxide (TBHP) mediated highly regioselective sulfonylation?cyclization?aromatization process between N-(3-aryl/heteroarylprop-2-yn-1-yl)quinolin-3-amines and aryl/heteroaryl sulfonylhydrazides. This synthetic protocol offers one-step strategy for C | |
| Keywords: | Transition-metal-free One-pot C-S & C-C bonds formation Atom-economy Cytotoxic agents |
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