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Isolation and structure determination of lysiformine from bacteria associated with marine sponge Halichondria okadai
Authors:Sou Kikuchi  Kayo Okada  Yuko Cho  Shinichiro Yoshida  Eunsang Kwon  Mari Yotsu-Yamashita  Keiichi Konoki
Institution:1. Graduate School of Agricultural Science, Tohoku University, Aoba, Sendai 980-8572, Japan;2. Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Aoba, Sendai 980-8578, Japan
Abstract:Marine sponge Halichondria okadai is a source of numerous toxic secondary metabolites, which are considered as products of the symbiotic species associated with the sponge. In this study, we tested 720 culture conditions and purified 48 sponge-associated microbes. The ethyl acetate extract from the liquid culture of each species was tested for cytotoxicity, hemolytic activity, and brine shrimp lethal activity. Lysiformine (1) was isolated from Lysinibacillus fusiformis and its structure was determined by HRMS and NMR.
Keywords:Isolation  Structure determination
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