A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala |
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| Authors: | Yuben Qiao Yanfei Liu Xueyan Duan Chunmei Chen Junjun Liu Hucheng Zhu Yongbo Xue Yonghui Zhang |
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| Institution: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People''s Republic of China;2. The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan 430014, People''s Republic of China |
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| Abstract: | Caesaldecins A and B (1a/1b), a pair of epimeric cassane-type diterpenoids containing an ether linkage between C-6 and C-20 and an α,β-butenolide ring in the northern hemisphere, were isolated from the leaves of the medicinal plant Caesalpinia decapetala (Roth) Alston, along with a new labdane-type diterpenoid, termed as 8(17),11(Z),13(E)-trien-15,18-dioic acid (2). Structures of 1 and 2 were established by extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) calculations. The in vitro antibacterial and inhibitory activities against a panel of bacteria and cancer cell lines were evaluated, respectively. Compound 2 displayed moderate antibacterial activity against the methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA) with an MIC50 value of 5.99?μg?mL?1. |
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| Keywords: | Cassane-type furanoditerpenoid Mixture of epimers ECD calculations Antibacterial activities |
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