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Efficient acid catalytic synthesis of pyrazolopyrimidines from 1H-pyrazol-5-yl-N,N-dimethylformamidines with cyanamide |
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| Authors: | Shuo-En Tsai Wan-Ping Yen Ching-Chun Tseng Jia-Jun Xie Ming Yu Liou Yi-Ting Li Naoto Uramaru Fung Fuh Wong | |
| Institution: | 1. School of Pharmacy, China Medical University, No. 91, Hsueh-Shih Rd., Taichung, 40402, Taiwan;2. Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung, 40402, Taiwan;3. Master Program for Pharmaceutical Manufacture, China Medical University, No. 91, Hsueh-Shih Rd., Taichung, 40402, Taiwan;4. Department of Environmental Science, Nihon Pharmaceutical University, 10281, Komuro, Ina-machi, Kitaadachi-gun, Saitama, Japan | |
| Abstract: | The efficient acid catalytic synthesis of pyrazolo 3,4-d]pyrimidine was developed by treating 1H-pyrazol-5-yl-N,N-dimethylformamidine with various aminating agents including N,O-bis(trimethylsilyl)hydroxylamine (NHSiMe3(OSiMe3)), cyanamide (NH2C | |
| Keywords: | Pyrazolopyrimidines Cyanamide Formamidines Heterocyclization | |
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