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Cu-catalyzed reduction of azaarenes and nitroaromatics with diboronic acid as reductant |
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| Authors: | Danwei Pi Haifeng Zhou Yanmei Zhou Qixing Liu Renke He Guanshuo Shen Yasuhiro Uozumi |
| Affiliation: | 1. Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China;2. Institute for Molecular Science, Myodaiji, Okazaki 444-8787, Japan |
| Abstract: | A ligand-free copper-catalyzed reduction of azaarenes with diboronic acid as reductant in an aprotic solvent under mild conditions has been developed. Most interestingly, the nitroazaarenes could be reduced exclusively to give the corresponding amines without touching the azaarene moieties. Furthermore, the reductive amination of aromatic nitro compounds and aromatic aldehydes has also been realized. A series of hydrogenated azaarenes and secondary amines were obtained with good functional group tolerance. |
| Keywords: | Reduction Homogeneous catalysis Nitrogen heterocycles Quinolines Amination Aldehydes Diboronic acid Copper |
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