Aerobic intramolecular aminothiocyanation of unactivated alkenes promoted by in situ generated iodine thiocyanate |
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Authors: | Yangyang Feng Muhammad Ijaz Hussain Xiaohui Zhang Jian Shi Wen Hu Yan Xiong |
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Institution: | 1. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China;2. Chengdu Easton Biopharmaceuticals Co. Ltd, Chengdu, 611731, China |
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Abstract: | Aerobic intramolecular aminothiocyanation of unactivated alkenes has been developed by in situ generated iodine thiocyanate under open-flask conditions. This protocol provides a concise and efficient method for synthesizing SCN-containing pyrrolidine, piperidine and indoline derivatives with isolated yields of up to 87%. Furthermore, mixing iodine and sodium thiocyanate with oxygen afforded iodine thiocyanate (ISCN) and dithiocyanatoiodate I(SCN)2]- which were testified by liquid chromatography mass spectrometry. A mechanistic investigation indicates that iodonium ion and sulfonium ion intermediates might be involved in this transformation. |
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Keywords: | Aminothiocyanation Dithiocyanatoiodate Iodine thiocyanate Iodonium ion Sulfonium ion |
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