Cu(I)-catalyzed one-pot reactions of isatins,indoles, and amines toward unsymmetrically substituted 2-carbonylarylureas |
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| Authors: | Xiangjun Peng Xianyun Xu Shuangyang Chen Zeng Tian Liangxian Liu Qian Liu |
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| Affiliation: | 1. Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, PR China;2. School of Pharmaceutical Science, Gannan Medical University, Ganzhou 341000, PR China;3. Department of Pediatric Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR China;4. Experimental Teaching Centre of Medical Morphology, Basic Medical Sciences School of Gannan Medical University, Ganzhou 341000, PR China |
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| Abstract: | A series of unsymmetrical arylureas was obtained by the one-pot method for reacting isatins with indoles incorporating primary amino moieties, a significant heterocyclic skeleton for diverse pharmaceutically active structures. The reaction proceeds through Cu(I)-catalyzed C2 | |
| Keywords: | Unsymmetrical arylurea Isatin One-pot synthesis Antischistosomicidal activity |
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