A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant |
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| Authors: | Wei Zhan Ling Ji Ze-mei Ge Xin Wang Run-tao Li |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, China |
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| Abstract: | A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant has been developed. Using this procedure, a variety of nitriles could be smoothly transformed into the desired primary amides in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up. |
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| Keywords: | Hydrolysis of nitriles Continuous flow chemistry Green chemistry Hydrogen peroxide |
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