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Total synthesis of cyclopiamide A and speradine E |
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| Authors: | Mina C. Nakhla Kendall N. Weeks Mauricio Navarro Villalobos John L. Wood |
| Affiliation: | Department of Chemistry and Biochemistry, Baylor University, Waco, TX 76798, USA |
| Abstract: | Described is a total synthesis of the related alkaloids, cyclopiamide A and speradine E, via a unified strategy that also delivers the natural product aspergilline A. Key steps include metal-free conversion of a malonyl chloride and propargylamine to an intermediate pyrrolinone and a palladium catalyzed decarboxylation/aromatization sequence that delivers the requisite tetracyclic core. |
| Keywords: | Total synthesis Cyclopiamide A Aspergilline A speradine E Natural products Indole alkaloids |
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