Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations |
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| Authors: | Changli Sun Chunyan Zhang Xiangjing Qin Xiaoyi Wei Qing Liu Qinglian Li Jianhua Ju |
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| Institution: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China;2. Key Laboratory of Plant Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;3. State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China;4. University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China |
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| Abstract: | Naphthoquinone macrolides have attracted considerable synthetic interest due to their unique scaffolds, but there was no completion of total synthesis reported. In this study, genome mining and genetic manipulations were applied to stimulate the production of naphthoquinone macrolides from the deep-sea actinomycete Streptomyces olivaceus SCSIO T05; as a result, new metabolites olimycins A and B (1, 2) were isolated. The structures were elucidated on the basis of extensive spectroscopic data and X-ray single crystal diffraction studies. The results of these efforts enabled rectification of a key structural error made during previous efforts to characterize naphthoquinone macrolides. |
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| Keywords: | Genome mining Naphthoquinone macrolides Absolute configuration Structure rectification |
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