An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device |
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Authors: | Matthew O Brien,April Hall,John Schrauwen,Joyce van der Made |
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Affiliation: | 1. School of Chemical and Physical Sciences, Lennard-Jones Laboratories, Keele University, Borough of Newcastle-under-Lyme, Staffordshire, ST5 5BG, UK;2. Avans University of Applied Sciences, Lovensdijkstraat 61 – 63, 4818 AJ, Breda, North Brabant, The Netherlands |
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Abstract: | Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards. |
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Keywords: | Low-cost-automation Open-source Python OpenCV Raspberry-Pi Flow-chemistry Amide-formation Liquid-liquid extraction |
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