Synthesis of furo[3,2-c]coumarins via I2/TBHP-mediated reaction of 4-hydroxycoumarins with terminal alkynes |
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| Authors: | Xianglong Chu Ziqiang Tang Jiangshan Ma Libowen He Lei Feng Chen Ma |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, PR China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China |
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| Abstract: | An efficient I2/TBHP-mediated process for the formation of furo[3,2-c]coumarins from readily available materials has been developed. This process for the formation of furo[3,2-c]coumarins is quite environmental friendly and atom-economical. |
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| Keywords: | Transition-metal free Coupling/cyclization |
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