Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells |
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Authors: | Mahnoosh Rashidi Mohammad Reza Islami Saeed Esmaeili-Mahani |
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Institution: | 1. Chemistry Department, Shahid Bahonar University of Kerman, 76169 Kerman, Iran;2. Biology Department, Shahid Bahonar University of Kerman, 76169 Kerman, Iran |
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Abstract: | To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy. |
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Keywords: | β-lactam β-Lactone 2 4-Dichlorophenoxyacetic acid Ketene Anticancer |
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