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Synthesis of 10-membered and larger rings via free radical methods |
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| Authors: | L Germán López-Valdez Holber Zuleta-Prada Benito Reyes-Trejo Erick Cuevas-Yañez |
| Institution: | 1. Laboratorio de Productos Naturales, Área de Química, Departamento de Preparatoria Agrícola, Universidad Autónoma Chapingo, Apartado 74, Oficina de Correos Chapingo, Km 38.5 carretera México-Texcoco, Chapingo, México 56230, Mexico;2. Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco Km 14.5, Toluca, Estado de México 50200, Mexico |
| Abstract: | The purpose of this review is to discuss 1) how free radical chemistry has contributed to development of new methodologies for the construction of 10-membered and larger macrocycles over the past 32 years; 2) the most well-developed free radical methods for constructing 10-membered and larger rings; and 3) how these methodologies have contributed to solving certain key steps in the synthesis of natural products. |
| Keywords: | Macrocyclization reaction Medium-sized rings Macrocyclic natural products 10-Membered rings Free radical methods |
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