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Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents
Authors:Radim Horák  Lubomír Kvapil  Kamil Motyka  Ludmila Slaninová  Martin Grepl  Kamil Ko?istek  Miroslav Urbá?ek  Pavel Hradil  Miroslav Soural
Institution:1. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 5, 779 00, Olomouc, Czech Republic;2. Department of Organic Chemistry, Faculty of Science, Palacky University Olomouc, t?. 17. listopadu 12, 771 46, Olomouc, Czech Republic
Abstract:2-Alkenyl-3-hydroxyquinolin-4(1H)-ones were prepared by the rearrangement of anthranilic acid esters synthesized by two alternative methods. The prepared derivatives were screened for their antimicrobial activities against representative Gram-positive and Gram-negative bacteria, displaying notable minimum inhibitory concentration values against specific strains. The emission spectra of the target quinolines exhibited two well-separated emission bands, and the maximum excitation wavelengths of the selected compounds were detected at relatively high values.
Keywords:Anthranilates  Quinolinones  Rearrangement  Antibacterial  Fluorescence
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