Simple synthesis of alpha-hydroxyamino carbonyl compounds: new scope of the nitroso aldol reaction |
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| Authors: | Momiyama Norie Yamamoto Hisashi |
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| Institution: | Graduate School of Engineering, Nagoya University, SORST, Japan Science and Technology Corporation (JST), Chikusa, Nagoya 464-8603, Japan. |
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| Abstract: | reaction: see text] The reaction of nitroso compounds with enolates, "the nitroso aldol reaction", occurs in high yield to generate alpha-hydroxyamino carbonyl compounds. Yields range from 42% to 98% with N-selectivity >99:1 from commercially available aromatic or aliphatic nitroso compounds and a variety of alkali metal or tin enolates. |
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