Enantioselective alkylation of aldehydes with chiral organomagnesium amides (COMAs) |
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| Authors: | Yong Kelvin H Taylor Nicholas J Chong J Michael |
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| Affiliation: | Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, (GWC)(2), and Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1. |
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| Abstract: | [reaction: see text] Dialkylmagnesiums react with chiral secondary amines to form chiral organomagnesium amides (COMAs). These reagents alkylate aldehydes to form secondary alcohols with enantioselectivities up to 91:9 er. |
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