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Formal synthesis of erythrodiene and spirojatamol via rhodium-catalysed Claisen rearrangement/hydroacylation |
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| Authors: | Tim Sattelkau Peter Eilbracht |
| Affiliation: | Organische Chemie I (FB3), Universität Dortmund, Otto-Hahn-Str. 6, D-44227, Dortmund, Germany |
| Abstract: | A novel procedure allows the synthesis of spiro[4.5]decane-1,6-dione 1, a key intermediate in the total synthesis of erythrodiene and spirojatamol. The key step is a combination of Claisen rearrangement of allyl vinyl ethers followed by an intramolecular hydroacylation catalysed by RhCl(cod)(dppe). |
| Keywords: | Catalysis Natural Products Spiro Compounds |
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