Abnormal expression of centrosome protein (centrin) in spermatozoa of male human infertility |
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Authors: | Xiaodong Sun Jing Ma Yehua Ge Sai Li Zuoren Yu Shepu Xue Daishu Han |
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Institution: | (1) Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China |
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Abstract: | To study the relations between male infertility and centrosome protein (centrin) and the functions of centrin in spermatogenesis,
the matured spermatozoa of 10 normal male people and 18 male infertility patients were stained by immunofluorescence labeling
antibody against centrin. The results showed that two fluorescence signal dots appeared in the normal male spermatozoa and
were located at the base of flagellum. They are proximal centriole and distal centriole. However, in some spermatozoa of the
male infertility, centrin protein was located abnormally at the base of flagellum and its staining signals were spread, the
normal proximal and distal centrioles were confused and could not be recognized separately. These results suggest that abnormality
of centrosome protein may be related to male infertility. This discovery may be used as a marker of abnormal sperm and male
infertility. |
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Keywords: | centrin centrosome male infertility spermatozoa |
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