Developing novel activity-based fluorescent probes that target different classes of proteases |
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Authors: | Zhu Qing Girish Aparna Chattopadhaya Souvik Yao Shao Q |
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Affiliation: | Department of Chemistry, National University of Singapore, Singapore. |
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Abstract: | In this article, we report the design and synthesis of a group of novel activity-based probes that target different protease sub-classes based on their substrate specificities, rather than their enzymatic mechanisms. The feasibility of our approach has been demonstrated by using representative members of the different protease sub-classes. |
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