Synthesis and antibacterial properties of new phenothiazinyl- and phenyl-nitrones |
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Authors: | Hermina Iulia Petkes Emese Gál Luiza G?in? Mihaela Sabou Cornelia Majdik Lumini?a Silaghi-Dumitrescu |
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Institution: | 1. Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai” University, Kogalniceanu 1, 400084 Cluj-Napoca, Romania;2. Faculty of Medicine, “Iuliu Hatieganu”, University of Medicine and Pharmacy, Victor Babes 41, 400012 Cluj-Napoca, Romania |
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Abstract: | The synthesis of new phenothiazinyl- and phenyl-nitrones under classical versus microwave heating conditions is described. Better yields were obtained under microwave irradiation in the condensation reactions of phenothiazyl-carbaldehyde with hydroxylamine derivatives. The structures of the new phenothiazinyl-nitrones were assigned on the basis of MS, FT–IR and NMR spectra. The new nitrones and some known phenyl-nitrones were screened for their antibacterial and antifungal activity against several Candida species, Gram negative bacteria, such as E. coli, Citrobacter spp, Morganella spp, Pseudomonas aeruginosa, Klebsiella pneumoniae (± ESBL), Proteus spp, Acinetobacter spp and the Gram positive bacterium Staphylococcus aureus, with moderate results. |
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Keywords: | Phenothiazinyl-nitrones Phenyl-nitrones Antifungal activity Microwave-assisted synthesis Fluorescence |
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