Highly water-soluble,near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging |
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Authors: | Shilei Zhu Jingtuo Zhang Jagadeesh Janjanam Jianheng Bi Giri Vegesna Ashutosh Tiwari Fen-Tair Luo Jianjun Wei Haiying Liu |
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Affiliation: | 1. Department of Chemistry, Michigan Technological University, Houghton, MI 49931, United States;2. Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan, ROC;3. Biomedical Technology Branch, CFD Research Corporation, Huntsville, AL 35805, United States |
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Abstract: | Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to αvβ3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells. |
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Keywords: | BODIPY dye Conjugated polymer Cancer imaging Fluorescence RGD peptide |
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