Aligned electrospun nanofibers for ultra-thin layer chromatography |
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Authors: | Michael C Beilke Joseph W ZeweJonathan E Clark Susan V Olesik |
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Institution: | Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, United States |
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Abstract: | The fabrication and implementation of aligned electrospun polyacrylonitrile (PAN) nanofibers as a stationary phase for ultra-thin layer chromatography (UTLC) is described. The aligned electrospun UTLC plates (AE-UTLC) were characterized to give an optimized electrospun mat consisting of high nanofiber alignment and a mat thickness of ∼25 μm. The AE-UTLC devices were used to separate a mixture of β-blockers and steroidal compounds to illustrate the properties of AE-UTLC. The AE-UTLC plates provided shorter analysis time (∼2–2.5 times faster) with improved reproducibility (as high as 2 times) as well as an improvement in efficiency (up to100 times greater) relative to non-aligned electrospun-UTLC (E-UTLC) devices. |
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Keywords: | AE-UTLC aligned electrospun ultra-thin layer chromatography E-UTLC electrospun ultra-thin layer chromatography PAN polyacrylonitrile |
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