Highly sensitive detection of urinary cadmium to assess personal exposure |
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Authors: | Avni A. Argun Ashley M. Banks Gwendolynne Merlen Linda A. Tempelman Michael F. Becker Thomas Schuelke Badawi M. Dweik |
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Affiliation: | 1. Giner, Inc., 89 Rumford Ave., Newton 02466, MA United States;2. Fraunhofer USA – CCL, 1449 Engineering Research Ct., East Lansing 48824, MI, United States |
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Abstract: | A series of Boron-Doped Diamond (BDD) ultramicroelectrode arrays were fabricated and investigated for their performance as electrochemical sensors to detect trace level metals such as cadmium. The steady-state diffusion behavior of these sensors was validated using cyclic voltammetry followed by electrochemical detection of cadmium in water and in human urine to demonstrate high sensitivity (>200 μA ppb−1 cm−2) and low background current (<4 nA). When an array of ultramicroelectrodes was positioned with optimal spacing, these BDD sensors showed a sigmoidal diffusion behavior. They also demonstrated high accuracy with linear dose dependence for quantification of cadmium in a certified reference river water sample from the U.S. National Institute of Standards and Technology (NIST) as well as in a human urine sample spiked with 0.25–1 ppb cadmium. |
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Keywords: | Boron-Doped Diamond (BDD) Ultramicroelectrode array Electrochemical sensors Urinary trace metal detection Cadmium Differential pulse stripping voltammetry (DPSV) |
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