Polysulfobetaine films prepared by electrografting technique for reduction of biofouling on electroconductive surfaces |
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Authors: | Marek Stach Zuzana KronekováPeter Kasák Jozef KollárMartin Pentrák Matej Mi?ušíkDušan Chorvát Jr Tim S NunneyIgor Lacík |
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Institution: | a Polymer Institute of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava 45, Slovak Republic b Institute of Inorganic Chemistry of the Slovak Academy of Sciences, Dúbravská cesta 9, 845 36 Bratislava, Slovak Republic c International Laser Centre, Ilkovi?ova 3, 841 04 Bratislava, Slovak Republic d Thermo Fisher Scientific, The Birches Industrial Estate, Imberhorne Lane, East Grinstead RH19 1UB, United Kingdom |
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Abstract: | The sulfobetaine films were prepared on stainless steel and golden surfaces. In the first step, the poly(2-(dimethylamino)ethyl methacrylate) film was created by employing the electrografting polymerization technique. In the second step, this film was modified to polysulfobetaine, i.e. the polymer film bearing the zwitterionic groups. The presence of the electrografted film and its modification were determined by contact angle measurements, infrared spectroscopy in reflectance mode and X-ray photoelectron spectroscopy. The prepared films were homogeneous with the thickness from about 5 to 26 nm as determined by X-ray photoelectron spectroscopy. The atomic force microscopy measurements showed the increase of surface roughness upon the surface coating. In vitro tests using adherent RAT-2 fibroblast cells and fluorescently labelled bovine serum albumin proteins showed that prepared polysulfobetaine films can be used in applications requiring the resistance against cell attachment and biofouling. |
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Keywords: | Electrografting Zwitterions XPS ATR-FTIR CLSM Contact angle Biofouling 2-(Dimethylamino)ethyl methacrylate Sulfobetaine |
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