Thermal Stability Of Folic Acid in the solid-state |
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Authors: | Vora A Riga A Dollimore D Alexander K |
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Institution: | (1) College of Pharmacy, Pharmacy Practice Department, The University of Toledo, Toledo, OH, 43606 |
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Abstract: | This study attempts to identify the degradative process which folic acid undergoes in the solid-state under thermal stress.
In order to facilitate the process, the various pieces of the chemical structure, namely, p-amino benzoic acid, pterin and glutamic acid as both its d- and l-isomers were investigated as separate entities. These structured solid-state pieces were then compared to the composite solid
state folic acid degradative curves in order to identify the peaks seen and provide direction for the interpolation of the
degradative mechanism. It was observed that none of the structural pieces could be superimposed as assumed earlier and hence
an attempt was made to identify the decomposition products using various analytical techniques such as infrared spectroscopy,
mass spectroscopy and X-ray diffraction which suggested that the glutamic acid fragment is lost first as evidenced by acid
loss and amide enhancement in the IR spectra. The vitamin was ultimately degrading to carbon fragments and that further identification
was not necessary.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | mass spectrometry thermal stability solid-state infrared spectroscopy degradation pathway X-ray crystallography folic acid |
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