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Enzyme dynamics and catalysis in the mechanism of DNA polymerase |
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| Authors: | Adrian J. Mulholland Adrian E. Roitberg I?aki Tu?ón |
| Affiliation: | 1. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK 2. Department of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL, 32611-8435, USA 3. Departamento de Química Física, Universidad de Valencia, 46100, Burjasot, Spain |
| Abstract: | This contribution contains the commentaries of the three authors about two papers in this issue of TCA that present alternative views of the role of conformational changes in the specificity of enzyme DNA polymerase β. Concepts such as dynamical effects, the induced fit model or the importance of sampling in modeling of enzymatic reactions are briefly revised within the context of the debate established in the two previous papers. |
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