A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin |
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| Authors: | Subhash P Chavan Sumanta Garai Chandan Dey Rajesh G Gonnade |
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| Institution: | 1. Division of Organic Chemistry, CSIR-NCL (National Chemical Laboratory), Pune 411008, India;2. Physical/Materials Chemistry Division, CSIR-NCL (National Chemical Laboratory), Pune 411008, India |
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| Abstract: | A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin has been achieved from readily available starting materials via unified strategy employing Sharpless asymmetric dihydroxylation, ring closing metathesis, Overman rearrangement, hydrogenolysis and Bischler–Napieralski reaction in 15 purification steps with 15% overall yield. |
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| Keywords: | Amaryllidaceous alkaloids 7-Deoxypancratistatin Epimer Sharpless asymmetric dihydroxylation Deoxygenation |
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