Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives |
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Authors: | Pradeep Chopra Paul D MadgeRobin J Thomson I Darren GriceMark von Itzstein |
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Institution: | Institute for Glycomics, Griffith University Gold Coast Campus, Queensland 4222, Australia |
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Abstract: | A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more traditional methods, with optimised NaOH-promoted de-N-acetylation in only 15 min. The prepared amines were readily re-N-acylated to afford the corresponding N-glycolyl (Neu5Gc) analogues. |
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Keywords: | Sialic acid Microwave de-N-acetylation N-Glycolylneuraminic α-2 8-Polysialic acid |
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