A one-pot stereoselective synthesis of novel polyfunctionalized imidazolidines |
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Authors: | Abolfazl Olyaei Mohsen Karbalaei KarimiReza Razeghi |
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Institution: | Department of Chemistry, Payame Noor University, PO 19395-3697, Tehran, Iran |
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Abstract: | A facile, one-pot stereoselective synthesis of novel trans-4,5-dihydroxy-2-aryl-1,3-bis(heteroaryl)imidazolidines is achieved by a cyclocondensation reaction of 2 equiv of heteroarylamines with benzaldehyde derivatives, in the presence of guanidinium chloride as a polyfunctional organocatalyst, with aqueous glyoxal to afford the title products. This general protocol provides a wide range of new polyfunctionalized imidazolidines in good to high yields. |
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Keywords: | Heteroarylamine Aldehyde Imidazolidine Glyoxal |
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