An efficient ionic liquid mediated synthesis of substituted 5H[1,3]-thiazolo[2,3-b]quinazoline-3,5-(2H)-dione and 5H-thiazolo[2,3-b]quinazolin-5-one |
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Authors: | Ashok K Yadav Pankaj DhakadGopi Ram Sharma |
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Institution: | Department of Chemistry, University of Rajasthan, Jaipur 302004, India |
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Abstract: | A new, environmentally benign two-step synthesis of 5H1,3]-thiazolo2,3-b]quinazoline-3,5-(2H)-dione and 5H-thiazolo2,3-b]quinazolin-5-one derivatives has been accomplished stepwise. The substituted 2-aminobenzoic acid upon condensation with thiourea in 1-butyl-3-methylimidazolium bromide at moderate temperature under nitrogen atmosphere yielded 2-thioxo-1H-4-quinazolinones. The resulting intermediate 2-thioxo-1H-4-quinazolinones, when reacted with 2-chloroethanoic acid/2-chloropropanal underwent cyclization to yield the desired product in excellent yields. |
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Keywords: | Quinazolinethiones Thiazoloquinazolinone Thiazoloquinazolindione Ionic liquid |
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