Simplified syntheses of the water-soluble chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta |
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| Authors: | Lucie Hrubá Miloš Buděšínský Jan Pícha Jiří Jiráček Václav Vaněk |
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| Institution: | 1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic;2. Department of Analytical Chemistry, Charles University, Hlavova 2030, 128 40 Prague 2, Czech Republic |
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| Abstract: | The chiral shift reagents Sm-(R)-pdta and Sm-(S)-pdta, which are based on (R)- or (S)-1,2-diaminopropane-N,N,N′,N′-tetraacetic acid were synthesized from easily accessible compounds in three simple steps, which makes the method suitable for laboratory-scale production. In addition, a new and efficient method for the preparation of pure anhydrous (R)- or (S)-1,2-diaminopropane-N,N,N′,N′-tetraacetic acid was developed. |
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| Keywords: | NMR Chiral shift reagents Sm-pdta PDTA Samarium 1 2-Diaminopropane |
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