Recyclable cinchona alkaloid catalyzed asymmetric Michael addition reaction |
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| Authors: | Xin Huang Wen-Bin YiDanash Ahad Wei Zhang |
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| Affiliation: | Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA |
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| Abstract: | A highly enantioselective and diastereoselective Michael addition reaction of α-fluoro-β-ketoesters with maleimides is catalyzed by fluorous cinchona alkaloid to afford two adjacent chiral centers. The catalyst attached with a perfluroalkyl tag can be recovered by fluorous solid-phase extraction (F-SPE). |
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| Keywords: | Organocatalysis Asymmetric synthesis Cinchona alkaloid Fluorous Michael addition |
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