Catalyst free,regioselective one-pot three-component synthesis of thiazol-2-imine derivatives in ionic liquid |
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| Authors: | G. Santosh Kumar S. Pushpa RaginiH.M. Meshram |
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| Affiliation: | Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A one-pot three-component approach for the synthesis of thiazol-2-imines has been described by the reaction of amine, phenyl isothiocyanate and β-nitroacrylate in [Hbim]BF4 ionic liquid. The method is applicable for aromatic, benzylic, aliphatic and cyclic amines. Reusable reaction media, regioselectivity, mild reaction condition, catalyst free and high yield of products are the salient features of this protocol. |
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| Keywords: | Amine Phenyl isothiocyanate β-Nitroacrylate Thiazol-2-imines Regioselectivity and ionic liquid |
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