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Synthesis of α-alkenyl-α-amino esters via addition of potassium Alkenyltrifluoroborate salts to imine in the presence of Yb(OTf)3 |
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| Authors: | Hélio A Stefani Amna N Khan Flávia Manarin Pedro H Vendramini Marcos N Eberlin |
| Institution: | 1. Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil;2. Instituto de Química, Universidade Estadual de Campinas, Campinas, SP, Brazil |
| Abstract: | A simple protocol which led to an effective construction of α-alkenyl-α-amino esters was achieved under mild conditions. This transformation proceeded by Yb-catalyzed addition of alkenyltrifluoroborates across the imine double bond. A variety of functional groups could be applicable to both partners. |
| Keywords: | Vinyltrifluoroborate Amino acid Addition reaction Lewis acid Ytterbium |
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