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RGD-conjugated triarylmethyl radical as probe for electron paramagnetic imaging |
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| Authors: | Benoît Driesschaert Philippe Levêque Bernard Gallez Jacqueline Marchand-Brynaert |
| Institution: | 1. Institute of Condensed Matter and Nanosciences (IMCN), Molecules, Solids and Reactivity (MOST), Université catholique de Louvain, Place Louis Pasteur 1, L4.01.02, B-1348 Louvain-la-Neuve, Belgium;2. Louvain Drug Research Institute (LDRI), Biomedical Magnetic Resonance Section (REMA), Université Catholique de Louvain, Avenue Mounier 73, B1.73.08, B-1200 Bruxelles, Belgium |
| Abstract: | A stable RGD-conjugated triarylmethyl (TAM) radical 3 has been synthesized in a straightforward three-step sequence. CT-03 ‘the Finland trityl’ which is a very popular contrast agent for electron paramagnetic resonance imaging has been covalently bound to the NH2-ending of a pentapeptide commonly used to target integrins and confers tissue selectivity. Moreover, this new TAM radical is stable and sensitive to molecular oxygen. |
| Keywords: | EPR Trityl radical Oximetry RGD |
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