Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae |
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Authors: | Xiao-Long Yang Takayoshi Awakawa Toshiyuki Wakimoto Ikuro Abe |
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Affiliation: | 1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;2. College of Pharmaceutical Science, Hebei University, Baoding 071002, PR China |
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Abstract: | Concomitant supplementation of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid, and a DNA methyltransferase inhibitor, 5-azacytidine, to the culture medium of a plant endophytic fungus, Pestalotiopsis acaciae, dramatically altered its metabolic profiles. As a result, three novel aromatic compounds, 2′-hydroxy-6′-hydroxymethyl-4′-methylphenyl-2,6-dihydroxy-3-(2-isopentenyl)benzoate (1), 4,6-dihydroxy-7-hydroxymethyl-3-methylcoumarin (2) and 4,6-dihydroxy-3,7-dimethylcoumarin (3), were isolated, along with five known polyketides, endocrocin (4), pestalotiollide B (5), pestalotiopyrone G (6), scirpyrone A (7) and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (8). |
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Keywords: | Epigenetic modifier Endophytic fungi Pestalotiopsis acaciae Coumarin |
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