First total synthesis of neurotrophic diacetylene tetrol (−)-petrosiol D |
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| Authors: | A Sathish Reddy P Srihari |
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| Institution: | Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India |
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| Abstract: | The first total synthesis of the natural product (−)-petrosiol D has been achieved in a linear fashion. Sharpless asymmetric epoxidation, base induced elimination reaction for the formation of chiral propargyl alcohol and Cadiot–Chodkiewicz coupling reaction are the key steps utilized for the synthesis. |
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| Keywords: | Cadiot&ndash Chodkiewicz coupling Bromo acetylene Neurite Outgrowth Polyol Acetonide |
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