CeCl3·7H2O: a highly efficient catalyst for the synthesis of 1-substituted-octahydro-[1,3,2]diazaphospholo[1,5-a]pyridine-1-oxide |
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Authors: | Radha Rani Chinthaparthi Chandra Sekhar Reddy Gangireddy Veeranarayana Reddy Mudumala Mohan Gundluru Nagaraju Chamarthi Suresh Reddy Cirandur |
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Institution: | 1. Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India;2. Department of Chemistry, Sri Venkateswara College of Engineering, Tirupati 517 507, India |
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Abstract: | An efficient and simple protocol is reported for the synthesis of a new class of 1-substituted-octahydro-1,3,2]diazaphospholo1,5-a]pyridine-1-oxides in good to excellent yield (88–95%) via Michaelis–Arbuzov rearrangement. Condensation of diamido phosphite with various halides at 60 °C using CeCl3·7H2O as a highly efficient catalyst afforded the products within a short period of reaction time. This procedure is mild, efficient, and non-toxic and stability of the catalyst is the merit of this process. Therefore, this protocol being environmentally benign and efficient, serves as an alternative procedure for the preparation of the title compounds. |
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Keywords: | XIYSNDMCYFYKPJ-UHFFFAOYSA-N ULTDIVVKZNHXBQ-UHFFFAOYSA-N WAVOUXIVVBDRHI-UHFFFAOYSA-N JJNFFMHQQAZLLV-UHFFFAOYSA-N QEYOSGLGRAVGQY-UHFFFAOYSA-N YUMHLRLCNKNEOM-UHFFFAOYSA-N UKJKIXFTBGSGCZ-UHFFFAOYSA-N QAZCWNYALFNFAX-UHFFFAOYSA-N OYGKTCWMJMKECQ-UHFFFAOYSA-N NSCFIEYHCQATMR-UHFFFAOYSA-N ZVINJCXLSZWCQC-UHFFFAOYSA-N VPPQQOFAHWLGAM-UHFFFAOYSA-N NMKMZIBEPYSMAK-UHFFFAOYSA-N KFLXIQBALRRJBR-UHFFFAOYSA-N AKLLVSJCDQLALI-UHFFFAOYSA-N INWDIXFVWIGJAF-UHFFFAOYSA-N OXXXXZGCTQIZGL-UHFFFAOYSA-N LNHYAJSIEDAWHQ-UHFFFAOYSA-N |
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