Electrochemical synthesis of amides: direct transformation of methyl ketones with formamides |
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Authors: | Haolai Huang Gaoqing YuanXianwei Li Huanfeng Jiang |
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Institution: | School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China |
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Abstract: | A direct transformation from methyl ketones to secondary or tertiary amides has been developed through a novel electrochemical approach and a wide scope of formamides could be utilized as the amide sources. This transformation was promoted by in situ generated iodine through electrolysis of sodium iodide under mild, metal-free conditions. This electrochemical procedure could avoid the use of stoichiometric iodine and afforded the target products in good to excellent yields. |
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Keywords: | IXRBLAFOAKRWBJ-UHFFFAOYSA-N |
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